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Glucose Metabolism in the Brain
Aug. 18th, 2008 02:36 pmBecause I know it's related to my migraines even if no one else's.
"Although the brain represents only 2% of the body weight, it receives 15% of the cardiac output, 20% of total body oxygen consumption, and 25% of total body glucose utilization. With a global blood flow of 57 ml/100 g·min, the brain extracts approximately 50% of oxygen and 10% of glucose from the arterial blood. Hence, the glucose utilization of the brain, as assessed by measuring the arterial–venous difference (22), is 31 mmol/100 g·min."
http://www.acnp.org/g4/gn401000064/CH064.HTML
"Brain energy metabolism is often considered to reflect predominantly, if not exclusively, neuronal energy metabolism. However, it is now clear that other cell types, namely neuroglia and vascular endothelial cells not only consume energy but also can play an active role in the flux of energy substrates to neurons. First, there is a quantitative consideration; although it is arduous to provide a definitive ratio between neurons and nonneuronal cells given the variability in figures obtained in various species, brain areas, and developmental ages using methods that are not easily comparable, it is clear that neurons contribute at most 50% of cerebral cortical volume (23). In addition there is clear evidence indicating that the astrocyte-to-neuron ratio increases with increasing brain size (67); this is an important consideration when approaching the study of the cellular bases of brain energy metabolism in humans. It is therefore clear that glucose reaching the brain parenchyma through the circulation should provide energy substrates to a variety of cell types, only a portion of which are neurons."
Let's see... Glucose is C6H12O6 which makese sense being the 3 building blocks of life right there. It is well knowm to have a hugely important effect in evolution -- especially with humans because the human brain's ability to have such a high glucose consumption is what makes humans more intelligent in the first place.
Glucose is most often found in carbohydrates and starches (duh) and what isn't used by the brain goes directly to muscles stored as glycogen (energy) and then to fat cells. Hmmmmmm.
SPECULATION:
Is it entirely possible that during migraines my "brain power" speeds up? Therefore creating a higher need for sugar? And does this have anything to do with the common (if nonsense) theory that my migraines are created simply because I "think too much"?
The thing that concerns me most if it was JUST related to glucose, I should do better with more fruit than say a Kit-Kat bar because the prior has much more glucose sugar in it.
Also I wonder if your bain can get its form of lactic acid from using up the glucose faster than it can produce it. I'm crazy.
Onto CFIDS though, it is more recently assumed/tested/etc. that in CFIDS the mitochondria themselves are being attacked. This stands with everything that CFIDS is and does including the scary disappearance of fingerprints.
http://www.sciencedaily.com/releases/2007/12/071203121430.htm If this is 100% real/accurate, it might exemplify why I have such "willpower" and also represent how much I sit there with a migraine resisting the temptationt to do things that would make me sicker. Also a little bit on the "other forms of sugar don't work!" note.
So the only thing that remains is there something in specifically sugar cane sugar that makes me able to process it better? Or is it just simply related to sucrose period? Sucrose is made up of glucose and fructose combined but shortening the ends instead of the middle. But usually the concern in today's society is that too much sucrose is leading to tooth decay and diabetes. Is it possible to be having too little?
"Although the brain represents only 2% of the body weight, it receives 15% of the cardiac output, 20% of total body oxygen consumption, and 25% of total body glucose utilization. With a global blood flow of 57 ml/100 g·min, the brain extracts approximately 50% of oxygen and 10% of glucose from the arterial blood. Hence, the glucose utilization of the brain, as assessed by measuring the arterial–venous difference (22), is 31 mmol/100 g·min."
http://www.acnp.org/g4/gn401000064/CH064.HTML
"Brain energy metabolism is often considered to reflect predominantly, if not exclusively, neuronal energy metabolism. However, it is now clear that other cell types, namely neuroglia and vascular endothelial cells not only consume energy but also can play an active role in the flux of energy substrates to neurons. First, there is a quantitative consideration; although it is arduous to provide a definitive ratio between neurons and nonneuronal cells given the variability in figures obtained in various species, brain areas, and developmental ages using methods that are not easily comparable, it is clear that neurons contribute at most 50% of cerebral cortical volume (23). In addition there is clear evidence indicating that the astrocyte-to-neuron ratio increases with increasing brain size (67); this is an important consideration when approaching the study of the cellular bases of brain energy metabolism in humans. It is therefore clear that glucose reaching the brain parenchyma through the circulation should provide energy substrates to a variety of cell types, only a portion of which are neurons."
Let's see... Glucose is C6H12O6 which makese sense being the 3 building blocks of life right there. It is well knowm to have a hugely important effect in evolution -- especially with humans because the human brain's ability to have such a high glucose consumption is what makes humans more intelligent in the first place.
Glucose is most often found in carbohydrates and starches (duh) and what isn't used by the brain goes directly to muscles stored as glycogen (energy) and then to fat cells. Hmmmmmm.
SPECULATION:
Is it entirely possible that during migraines my "brain power" speeds up? Therefore creating a higher need for sugar? And does this have anything to do with the common (if nonsense) theory that my migraines are created simply because I "think too much"?
The thing that concerns me most if it was JUST related to glucose, I should do better with more fruit than say a Kit-Kat bar because the prior has much more glucose sugar in it.
Also I wonder if your bain can get its form of lactic acid from using up the glucose faster than it can produce it. I'm crazy.
Onto CFIDS though, it is more recently assumed/tested/etc. that in CFIDS the mitochondria themselves are being attacked. This stands with everything that CFIDS is and does including the scary disappearance of fingerprints.
http://www.sciencedaily.com/releases/2007/12/071203121430.htm If this is 100% real/accurate, it might exemplify why I have such "willpower" and also represent how much I sit there with a migraine resisting the temptationt to do things that would make me sicker. Also a little bit on the "other forms of sugar don't work!" note.
So the only thing that remains is there something in specifically sugar cane sugar that makes me able to process it better? Or is it just simply related to sucrose period? Sucrose is made up of glucose and fructose combined but shortening the ends instead of the middle. But usually the concern in today's society is that too much sucrose is leading to tooth decay and diabetes. Is it possible to be having too little?
